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This Medication Guide has been approved by the U.SFood and Drug Administration.

75 mg PO qDay without a loading doserecommended as alternative to aspirin or concomitantly with aspirin if patient not at increased risk for bleeding but at high risk for cardiovascular disease.

DIMINISHED ANTIPLATELET EFFECT IN PATIENTS WITH TWO LOSS-OF-FUNCTION ALLELES OF THE CYP2C19 GENE.

Clopidogrel is metabolized to its active metabolite in part by CYP2C19Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibitionsee WARNINGS AND PRECAUTIONS

Figure 3Hazard Ratio for Patient Baseline Characteristics and On-Study Concomitant Medications/Interventions for the CURE Study.

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